与压力相关的神经通路对身体活动对心血管的益处的影响
Hadil Zureigat1, Michael T Osborne2, Shady Abohashem3
1Cardiovascular Imaging Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Journal of the American College of Cardiology
|April 17, 2024
概括
身体活动 (PA) 通过减少与压力相关的神经活动,有利于心血管健康. 这种效应在患有抑郁症的人中更为明显,突出了PA.
科学领域:
- 神经科学是一个神经科学.
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
背景情况:
- 将体力活动 (PA) 与心理和心血管疾病 (CVD) 的益处联系在一起的机制需要进一步阐明.
- 与压力相关的神经活动与增强心血管疾病风险有关,并与焦虑和抑郁有关.
研究的目的:
- 调查PA是否会减弱与压力相关的神经活动.
- 为了确定PA是否降低心血管疾病风险,部分通过神经机制.
- 为了检查PA的心血管疾病风险降低是否在抑郁症患者中更大.
主要方法:
- 分析了来自50359名大众医院布里格姆生物库参与者的PA调查数据.
- 在一个子集中的F-氧葡萄糖正子发射断层扫描/计算机断层成像,以测量与压力相关的神经活动 (杏仁体与皮质活动比率).
- 通过电子健康记录确定心血管疾病事件.
主要成果:
- 较高的PA与较低的与压力相关的神经活动 (AmygAC) 和降低心血管疾病事件相关.
- 降低的AmygaC部分调解了PA和降低心血管疾病风险之间的关联.
- 在患有先前抑郁症的个体中,PA显示出更大的心血管疾病风险降低,通过超越PA指南来放大好处.
结论:
- 身体活动可以通过调节大脑压力路径来降低心血管疾病风险.
- 这种神经机制可能解释了PA在抑郁症患者中观察到的放大心血管疾病风险降低.
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