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在冷藏的血小板缩物中生长了心理变质细菌的扩散

Sandra Ramirez-Arcos^1,2, Dilini Kumaran^1,2, Andrew Cap³

¹Medical Affairs and Innovation, Canadian Blood Services, Ottawa, Ontario, Canada.

|April 17, 2024

概括

心理变质细菌可以在冷藏的血小板缩物 (PC) 中生长,其中一些达到危险的水平. 与室温储存相比,冷藏仍然降低了PC中的细菌风险.

科学领域:

输血医学输血医学
微生物学微生物学
食品安全食品安全

背景情况:

血小板缩剂 (PC) 储存在20-24°C以保持功能,但这种温度支持细菌生长.
冰冷储存PC (CSP) 抑制了细菌的增殖,但对心理变异物种的数据有限.

研究的目的:

在冷藏血小板缩物 (CSP) 中研究常见和心灵变异性细菌物种的增殖.
为了比较CSP中的细菌生长与室温储存的PC.

主要方法:

八个实验室参与了一项涉及聚合和分割PC单元的研究.
单元中添加了金黄色葡萄球菌,Klebsiella肺炎菌,Serratia liquefaciens,Pseudomonas光菌和Listeria monocytogenes.这些病毒.
PC在20-24°C保存7天或1-6°C保存21天,并定期进行细菌负载评估.

主要成果:

所有测试的细菌在室温PC中繁殖,在第7天达到≤10^9 CFU/mL.
在CSP中,P. fluorescens和S. liquefaciens在第10天和第17天分别增长到~10^6和~10^5 CFU/mL.
在21日,L. monocytogenes在CSP中达到~10^2 CFU/mL,而S. aureus和K. pneumoniae没有增长.

结论:

心理变质细菌虽然是罕见的污染物,但可以在CSP中繁殖,P. fluorescens在14天前达到临床显著水平.
与室温储存相比,冷藏显著降低了PC中的细菌风险.
实施细菌检测或病原体减少技术可以提高CSP存储超过10天的安全性.

关键词:

血小板缩物的细菌污染.在血小板度中的细菌生长.冷藏的血小板缩剂血小板缩剂血小板缩剂血小板缩剂

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