对前线治疗的完整反应与台湾艾滋病毒相关淋巴瘤的长期生存有关
Wei-Li Ma1, Wang-Da Liu2, Hsin-Yun Sun3
1Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Oncology, National Taiwan University College of Medicine, Taipei, Taiwan.
概括
艾滋病毒感染者 (PLWH) 和淋巴瘤患者的结局在联合抗逆转录病毒疗法 (cART) 改善. 在淋巴瘤诊断之前获得完整的治疗反应和更短的cART持续时间与更好的生存率相关.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 携带艾滋病毒 (PLWH) 和淋巴瘤的人的预后已通过联合抗逆转录病毒疗法 (cART) 和抗CD20单克隆抗体得到改善.
- 对于亚洲的这一患者群体,现实世界临床数据有限.
研究的目的:
- 为了检查亚洲的淋巴瘤PLWH的治疗结果.
- 根据淋巴瘤亚型和治疗反应来评估生存率.
主要方法:
- 对104名淋巴瘤患者 (2000-2019年) 的PLWH进行了回顾性分析.
- 队列包括霍奇金淋巴瘤 (HL),扩散大B细胞淋巴瘤 (DLBCL),伯基特淋巴瘤 (BL),初级中枢神经系统淋巴瘤 (PCNSL) 和其他亚型.
主要成果:
- 五年总生存率 (OS) 根据亚型不同:HL (100%),PCNSL (76.2%),其他 (60.0%),BL (57.4%),DLBCL (55.6%).
- 对前线治疗的完整反应 (CR) 显著改善了5年的生存率 (96.2%对17.8%).
- 诊断前较短的cART持续时间显示出更好的生存状况的趋势 (64.5%与51.9%相比).
结论:
- 患有DLBCL或BL的PLWH显示的OS率与HIV阴性患者相比较.
- 实现CR和更短的cART持续时间表明潜在的生物学差异和免疫参与淋巴瘤发病的发生.
- 需要进一步的研究来探索这些潜在的机制.
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