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相关概念视频

Reporter Genes02:11

Reporter Genes

11.3K
Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Transgenic Organisms00:53

Transgenic Organisms

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Overview
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Transgenic Plants02:50

Transgenic Plants

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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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What is Gene Expression?01:36

What is Gene Expression?

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A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
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相关实验视频

Updated: Jun 28, 2025

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
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Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

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TransGEM:基于变压器的分子生成模型,具有基因表达数据.

Yanguang Liu1, Hailong Yu1, Xinya Duan1

  • 1Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, P.R. China.

Bioinformatics (Oxford, England)
|April 17, 2024
PubMed
概括
此摘要是机器生成的。

人工智能与基于表型的药物设计相结合,为发现新的生物活性分子提供了一种新的方法. TransGEM模型利用基因表达数据生成具有潜在治疗应用的分子,独立于已知的疾病点.

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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
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Transient Gene Expression in Tobacco using Gibson Assembly and the Gene Gun

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科学领域:

  • 计算化学和化学信息学
  • 人工智能在药物发现中的作用
  • 基因组学和生物信息学

背景情况:

  • 传统的新药设计方法 (基于连接体和基于受体) 由于依赖分子标或疾病标信息的可用性而面临局限性.
  • 基于表型的de novo药物设计提供了一个替代策略,利用生物反应而不是特定的目标.
  • 基因表达特征是用于表征细胞表型的丰富信息来源.

研究的目的:

  • 引入TransGEM (基于转换器的模型从基因表达到分子),一种基于表型的新型药物设计模型.
  • 通过基因表达特征来证明TransGEM在产生新的生物活性分子方面的能力.
  • 探索人工智能和基于表型的方法在推动药物发现方面的潜力.

主要方法:

  • 开发TransGEM,一个基于变压器的深度学习模型,适用于新的药物设计.
  • 使用专门的基因表达编码器嵌入患病和正常细胞之间的基因表达差异.
  • 在变压器模型中使用注意力机制来识别与疾病表型相关的关键基因.

主要成果:

  • TransGEM成功地产生了具有有利评估指标和属性分布的分子.
  • 案例研究表明,TransGEM可以设计具有结构新的分子,对疾病点蛋白具有良好的结合亲和力.
  • 较高的注意力得分突出显示了与疾病发病相关的基因,这表明了潜在的治疗点.

结论:

  • TransGEM模型代表了基于表型的新药设计的重大进步.
  • 这种方法使得产生新型候选药物能够独立于对特定疾病点的先前知识.
  • 这项研究为药物发现建立了新的范式,有可能加速对各种疾病的治疗方法的识别.