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相关概念视频

Anatomy of the Intestines01:23

Anatomy of the Intestines

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Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

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The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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相关实验视频

Updated: Jun 28, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
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研究进展肠道微生物群通过肠-大脑轴调节认知功能.

Kaijie Lin1, Feng Peng1,2, Kunyang He1

  • 1School of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, China.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|April 17, 2024
PubMed
概括

肠道微生物组通过肠-大脑轴影响大脑功能和认知. 外科手术期间的肠道失调可能会导致神经认知功能障碍,需要新的预防策略.

关键词:
认知功能 认知功能我们的肠道微生物群.在外科手术期间出现的神经认知功能障碍.麻醉后/手术后的情况肠-大脑轴是肠-大脑轴.

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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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相关实验视频

Last Updated: Jun 28, 2025

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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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科学领域:

  • 微生物学 微生物学
  • 神经科学是一个神经科学.
  • 胃肠病学 胃肠病学

背景情况:

  • 肠道微生物群对于健康和疾病管理至关重要.
  • 肠-大脑轴将肠道微生物与中枢神经系统的认知调节联系起来.
  • 肠道微生物群通过神经和循环途径影响认知.

研究的目的:

  • 审查有关肠道微生物群对大脑和认知功能的影响的文献.
  • 探索神经和循环系统在这种相互作用中的作用.
  • 总结关于外科手术期间肠道失调和神经认知功能障碍的发现.

主要方法:

  • 现有研究的文献综述.
  • 对研究肠-大脑轴的研究进行分析.
  • 综合关于外科手术期间肠道失生症的发现.

主要成果:

  • 肠道微生物群显著影响认知功能.
  • 外科手术期间的肠道失调与神经认知功能障碍有关.
  • 肠-大脑轴是微生物对认知的影响的关键途径.

结论:

  • 肠道微生物群在认知功能中起着至关重要的作用.
  • 针对肠道微生物组的外科手术可能会预防神经认知功能障碍.
  • 需要进一步的研究来制定有效的预防和治疗策略.