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在老鼠中,regorafenib和阿托瓦斯塔丁之间的药理动力相互作用

Danuta Szkutnik-Fiedler1, Edyta Szałek1, Filip Otto2

  • 1Department of Clinical Pharmacy and Biopharmacy, Poznań University of Medical Sciences, Rokietnicka 3, 60-806, Poznań, Poland.

Pharmacological reports : PR
|April 17, 2024
PubMed
概括

在老鼠中同时使用阿托瓦斯塔丁和雷戈拉费尼布显著改变了它们的药理动力学. 阿托瓦斯塔丁增加了对雷戈拉芬尼的暴露,而雷戈拉芬尼降低了对阿托瓦斯塔丁代谢物的暴露,这表明临床显著的药物相互作用.

关键词:
一个阿托尔瓦斯塔丁.药物药物相互作用药理动力学 药理动力学雷戈拉费尼布的使用情况

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