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Updated: Jun 28, 2025

Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing
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Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

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通过跨物种单细胞转录组分析重建巨细胞和成年神经发生的演变

David Morizet1,2, Isabelle Foucher3, Alessandro Alunni3,4

  • 1Institut Pasteur, Université Paris Cité, CNRS UMR3738, Zebrafish Neurogenetics Unit, Team supported by the Ligue Nationale Contre le Cancer, F-75015, Paris, France. david.morizet@pasteur.fr.

Nature communications
|April 17, 2024
PubMed
概括

大质细胞对大脑功能至关重要,在哺乳动物中进化出了独特的特征. 这项研究揭示了它们的古代起源和在使用斑马鱼的脊椎动物进化中的多样化.

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Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

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Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain09:44

Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

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相关概念视频

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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