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Updated: Jun 28, 2025

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一种异常的化在肉瘤液滴中化的肌缩侧面硬化病变的病理变体R495X,加速了液体-固体相位过渡

Yutaro Shiramasa1, Ryu Yamamoto2, Norika Kashiwagi2

  • 1Graduate School of Pharmacy, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan.

Scientific reports
|April 17, 2024
PubMed
概括

缩在肉瘤 (FUS) 蛋白质聚合在肌缩侧面硬化症 (ALS) 中与液-液相分离 (LLPS) 有关. 异常高压LLPS的R495X FUS变体加速聚合,表明一个治疗目标.

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