年轻人糖尿病类型的错误诊断:患病率,特征和影响
Mustafa Tosur1,2, Xiaofan Huang3, Audrey S Inglis4
1The Division of Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 77030, USA. mustafa.tosur@bcm.edu.
Scientific reports
|April 17, 2024
概括
在年轻人中准确分类糖尿病是具有挑战性的. 大约6.4%的多样化的儿科患者在诊断时患有不正确的糖尿病类型,这突出了改善儿科糖尿病管理的诊断方法的需要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 代谢障碍 代谢障碍 代谢障碍
- 自免疫性疾病 自免疫性疾病
背景情况:
- 在诊断时准确的糖尿病分类对于有效的疾病管理至关重要.
- 糖尿病类型之间的临床特征重叠使青少年的诊断复杂化.
- 了解错误分类的流行率是改善儿科糖尿病护理的关键.
研究的目的:
- 为了确定糖尿病类型错误分类在多样化的儿科队列中的患病率和特征.
- 在诊断时识别与未知或修订型糖尿病类型相关的因素.
- 评估年轻人新发糖尿病的长期诊断准确性.
主要方法:
- 对2073名患有新发糖尿病的年轻人的回顾性分析.
- 基于内分泌学家诊断的未知与已知的糖尿病类型患者的比较.
- 在一个子队列 (n=1019) 中,对糖尿病类型重新分类的纵向评估超过3年.
主要成果:
- 糖尿病类型最初在3%的年轻人中是未知的,与年龄较大,阴性IA-2自身抗体,较低的C-和缺乏糖尿病酸性脂肪酸症有关.
- 糖尿病类型在纵向子队列中的3.4%被重新分类,没有特定的相关特征.
- 总体而言,6.4%的种族/种族多样性青年在诊断时经历了不准确的糖尿病分类.
结论:
- 很大一部分患有糖尿病的年轻人存在诊断不确定性或需要重新分类类型.
- 诸如年龄和特定的自身抗体状况等因素可能表明最初的诊断挑战.
- 进一步的研究对于完善诊断标准和提高儿科糖尿病类型的准确性至关重要.
相关概念视频
01:15Diabetes: Symptoms, Diagnosis, and Complications
528
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
528
01:22Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
01:22Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
01:20Pathophysiology of Diabetes
924
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
924
01:36Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
01:30Attention-Deficit/Hyperactivity Disorder
57
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
57