在COPD中肌肉损失表型与英国生物银行中的不良结果有关
Amy H Attaway1, Rocio Lopez2, Nicole Welch3,4
1Departments of Pulmonary Medicine, Cleveland Clinic, Cleveland, OH, USA.
BMC pulmonary medicine
|April 17, 2024
概括
肌肉损失表型 (MLP) 在慢性阻塞性肺病 (COPD) 患者中很常见. 鉴定COPD中的MLP至关重要,因为它显著增加了所有原因和COPD相关死亡率的风险.
科学领域:
- 肺部医学 肺部医学
- 老年病的医生 老年病的医生
- 临床营养学 临床营养学
背景情况:
- 慢性阻塞性肺病 (COPD) 是一种全身性炎症状况.
- 慢性肺炎可以导致肌肉损失表型 (MLP),其特征是肌肉质量,强度或两者都减少.
- 关于MLP患病率及其对大型COPD队列临床结果的影响的数据有限.
研究的目的:
- 为了确定基于人口的COPD队列中MLP的流行率.
- 调查MLP特征与所有原因和COPD相关死亡率之间的关联.
主要方法:
- 英国生物银行队列的回顾性分析.
- 通过FEV1/FVC比率,医生诊断或住院治疗来定义COPD.
- 使用无脂肪质量指数 (FFMI),尾骨肌肉指数 (ASMI),手握强度 (HGS) 和身体质量指数 (BMI) 评估MLP.
- 考克斯回归模型对多个共变量进行了调整,以评估死亡风险.
主要成果:
- 该研究包括55782名COPD患者,随访时间中位数为70.1个月.
- 在53.4%的COPD患者中存在MLP,ASMI和HGS是常见的指标.
- 患有MLP的COPD患者表现出所有原因死亡的风险比率高出30%,COPD相关死亡风险比率高出70%.
结论:
- 肌肉损失表型在COPD患者中非常普遍.
- MLP是COPD所有原因和COPD相关死亡率增加的重要预测因素.
相关概念视频
01:26COPD: Management Using Bronchodilators and Corticosteroids
198
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
198
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
01:20COPD: Pathogenesis and Clinical Features
267
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
267
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K