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Updated: Jun 28, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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通过USP18进行I型干扰素调节是癌症癌症的关键漏洞

Veronica Jové1, Heather Wheeler2, Chiachin Wilson Lee2

  • 1Centers for Therapeutic Innovation, Pfizer, New York City, NY 10016, USA.

iScience
|April 18, 2024
PubMed
概括

USP18蛋白的支架功能是癌细胞对I型干扰素反应的关键. 人类USP18具有最小的催化活性,与老鼠USP18不同,澄清了其药物开发机制.

关键词:
癌症 癌症 癌症 癌症细胞生物学 细胞生物学免疫反应的免疫反应.豁免权是一种豁免权.

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