在COVID-19第一波期间,与28天的危急疾病发展相关的因素
Uluhan Sili1,2, Pınar Ay3,2, Hüseyin Bilgin1,2
1Department of Infectious Diseases and Clinical Microbiology, Marmara University School of Medicine, İstanbul, Turkey.
Infectious diseases & clinical microbiology
|April 18, 2024
概括
在COVID-19患者中,危急疾病的预测因素包括年龄,并发症,前素和LDH水平. 世界卫生组织 (WHO) 的规模是最强的预测指标,结果比大流行病的第一波更好.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 第一波COVID-19大流行在预测疾病严重程度方面带来了独特的挑战.
- 识别危急疾病的早期指标对于及时干预和资源分配至关重要.
研究的目的:
- 在COVID-19患者入院后28天内定义危急疾病发展的预测因子.
- 分析与大流行初期严重疾病进展相关的因素.
主要方法:
- 对477名PCR阳性COVID-19患者的前性队列研究,这些患者被录入第三级护理医院.
- 多变量分析以确定危急疾病发展的独立预测因素.
主要成果:
- 在9.4%的患者中发生了危急疾病.
- 独立预测因素包括年龄,并发症数量,前素水平 (≥0.25μg/L) 和乳酸脱酶 (LDH) 水平 (≥350 U/L).
- 世界卫生组织 (WHO) 的临床改善标准是最强的预测指标 (HR=4.15). 在研究期间晚些时候住院的患者的预后更好.
结论:
- 年龄,并发症负担,世卫组织尺度,LDH和普卡尔西托尼是COVID-19中严重疾病的重要预测因素.
- 随着第一波疫情的进展,COVID-19死亡率的下降趋势被观察到.
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