双模态血管内导管系统结合了脉冲采样光终身成像和偏振敏感光学连贯性断层扫描
Julien Bec1, Xiangnan Zhou1, Martin Villiger2
1Biomedical Engineering, University of California, Davis, CA 95616, USA.
Biomedical optics express
|April 18, 2024
概括
一种新的血管内导管结合了光终身成像 (FLIm) 和偏振敏感光学连贯断层扫描 (PSOCT) 来进行全面的动脉样硬化斑块分析. 这种混合成像系统提供了详细的形态和生物化学见解,没有对比剂,推进心血管疾病诊断.
科学领域:
- 心血管成像 - 心血管成像
- 生物医学工程 生物医学工程
- 光学物理学 光学物理学
背景情况:
- 冠状动脉疾病的管理和急性冠状动脉综合征的预防取决于了解动脉样硬化斑块的病理生物学.
- 目前的成像方法可能缺乏对生物化学和形态斑块特征的全面评估.
研究的目的:
- 开发和实施一种新型的血管内导管系统,集成光终身成像 (FLIm) 和偏振敏感光学连贯断层扫描 (PSOCT).
- 为了能够在没有分子对比剂的情况下进行斑块结构和组成的多层次评估.
主要方法:
- 设计了一种低度 (2.7 Fr) 导管,使用双层纤维 (DCF) 和宽带,高回报损失旋转结.
- 该系统被优化,以减轻来自反射和多路径工件的OCT性能降低.
- 在四个光谱带和PSOCT参数 (强度,双折射,脱极化) 中获得了同时共同记录的FLIM数据.
主要成果:
- FLIm-PSOCT导管系统成功获得了幽灵,猪冠状动脉样本和猪心脏的多模式数据.
- 该系统展示了高速运行 (100 fps B-扫描,40 mm/s回撤).
- 获得了补充组织信息,包括形态,细胞外矩阵组成和炎症标志物.
结论:
- 这种一流的混合FLIm-PSOCT血管内导管提供了对动脉样硬化斑块的全面,多层次的评估.
- 该设备适用于穿皮冠状动脉干预,为心血管研究和临床诊断开辟了新的途径.
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