干涉计近红外光谱学 (iNIRS) 显示,血液流量指数取决于波长
Dibbyan Mazumder1,2, Oybek Kholiqov3, Vivek J Srinivasan1,2
1Department of Radiology, New York University Langone Health, New York, NY 10016, USA.
Biomedical optics express
|April 18, 2024
概括
血液流量指数 (BFI) 显示了人类前臂的波长依赖的增加,表明动态散射概率影响测量. 这一发现表明,在解释像激光光斑这样的光学测量时,需要谨慎.
科学领域:
- 生物医学光学 生物医学光学
- 医疗成像医学成像
- 生理监测 生理监测
背景情况:
- 血流指数 (BFI) 是评估组织输液的关键光学参数.
- BFI使用动态散射概率和扩散系数量化红细胞 (RBC) 运动.
- 现有的方法通常假定波长独立,这可能不适用于生物组织.
研究的目的:
- 为了研究BFI在人类前臂组织中的波长依赖性.
- 为了确定动态散射概率对BFI变化的贡献.
- 在RBC运动分析中评估波长对更高阶累积项的影响.
主要方法:
- 使用波长分割多重复合,飞行时间解析 (iNIRS) 系统.
- 在773nm和855nm获得的飞行时间解析场自相关性.
- 在人类前臂组织和动态散射幻影中测量了BFI.
主要成果:
- 前臂BFI表现出波长依赖的增加,从773nm增加到855nm (23%±19%).
- 在纯动态散射幻影中,BFI 保持波长独立.
- 红血细胞的高阶累积值值的平均平方位移随波长的增加而减少.
结论:
- 生物组织中BFI的波长依赖性归因于动态散射概率的波长依赖性.
- 红细胞的散射特性有助于观察到波长的BFI变化.
- 由于波长效应,建议在解释来自激光斑点和类似技术的场自相对应时谨慎.
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