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微型的多双色球仪器,用于测量多种光体度
Konstantin Grygoryev1, Huihui Lu1, Simon Sørensen1
1Tyndall National Institute, Lee Maltings Complex, Dyke Parade, Cork, Ireland.
Biomedical optics express
|April 18, 2024
概括
这项研究引入了用于脑瘤检测的小型光学系统,提高了手术精度. 该设备准确地测量光,帮助外科医生识别瘤边缘,以获得更好的患者结果.
科学领域:
- 生物医学光学 生物医学光学
- 手术技术 手术技术
- 在瘤学瘤学.
背景情况:
- 准确识别脑瘤边缘对于成功的手术切除和改善患者预后至关重要.
- 多形质母细胞瘤 (GBM) 透和可视化不良往往导致不完全切除 (高达80%),导致高复发率和低生存率.
- 目前的方法在动态范围和整合时间方面存在局限性,这阻碍了有效的手术内瘤边缘划分.
研究的目的:
- 开发和展示一个小型的,基于SiPMT的光学系统,用于同时测量扩散反射光谱 (DRS) 和自发光.
- 为了在手术切除过程中精确检测脑瘤边缘.
- 为改善手术内外科手术指导提供临床适应性工具.
主要方法:
- 设计了一个小型化的光学系统,尺寸为1.5 × 2 × 16毫米,集成了8个选择波长.
- 采用基于SiPMT的传感器,同时测量DRS和自动光信号.
- 使用混合光体 (NADH,FAD,PpIX) 和部分最小平方 (PLS) 回归的光学组织幻影验证了该系统.
主要成果:
- 在装配和实际光度之间实现了高相关系数 (NADH为0.95,FAD为0.87,PpIX为0.97).
- 证明了系统的动态能力,减去背景照明和测量信号从pW到mWs.
- 微型设计允许与现有的手术指导仪器无集成.
结论:
- 拟议的微型光学系统显示出在临床环境中有效检测脑瘤的显著前景.
- 这项技术可以帮助外科医生准确识别瘤边缘,可能导致更完整的切除和改善患者的治疗结果.
- 该系统比传统的基于光谱仪的系统具有优势,因为它具有广泛的动态范围和快速测量能力.
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