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柏柏林和对对大鼠的偏醇诱导的肝毒性有改善作用

Gamal Shams¹, Somia Abd Allah², Raghda Ezzat³

¹Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Open veterinary journal

|April 18, 2024

概括

柏柏林和通过增强抗氧化剂活性来保护对抗类诱导的肝损伤. 这种组合疗法在缓解急性肝毒性方面表现有前途.

科学领域:

药理学药理学是指药理学的学科.
毒理学毒理学毒理学
生物化学生物化学

背景情况:

降醇 (PCM) 过量服用是药物诱导的肝毒性的主要原因.
N-乙囊是标准的解毒剂,但需要新的治疗策略.
柏柏林 (BBR) 具有已知的抗氧化和抗炎性质.

研究的目的:

评估Berberine (BBR) 和的保护作用,单独或组合,对对 (PCM) 诱导的急性肝毒性.
评估这些药物对肝功能,氧化应激标志物和免疫反应的影响.

主要方法:

成年雄性白色老鼠被给予PCM以诱导肝毒性.
大鼠同时接受BBR (150毫克/千克) 和/或 (5毫克/千克) 的治疗.
评估包括肝功能测试,抗氧化酶活性,脂质过氧化标志物,免疫标志物和组织病理学分析.

主要成果:

结合BBR和显著改善了肝功能参数和抗氧化酶活动.
治疗降低了氧化 (NO),甲 (MDA),TNF-α和TGF-β1.1的水平.
观察到IgM水平升高和肝脏组织病理学改善.

结论:

柏柏林和,单独或一起,增强抗氧化能力.
这些药物有效地减轻了类醇诱导的肝毒性.
这些发现表明BBR和在管理PCM肝毒性方面可能具有治疗作用.

关键词:

柏柏林蛋白是一种柏柏林蛋白.诱导性肝毒性引起的肝毒性帕拉西他摩尔是一种可怕的药物.保护性保护性保护性是一种.

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