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Updated: Jun 28, 2025

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检测T细胞克隆扩张和量化克隆存活,使用免疫谱的深度分析

Anastasia V Pavlova1,2, Ivan V Zvyagin1,2,3, Mikhail Shugay1,2

  • 1Institute of Translational Medicine, Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.

Frontiers in immunology
|April 18, 2024
PubMed
概括

这项研究引入了一种新的生物信息学方法来追踪T细胞受体动态. 这种方法量化了T细胞谱的变化,提供了对移植和疫苗接种后免疫反应的见解.

关键词:
T细胞受体 (TCR) 是一种T细胞受体.分析T细胞谱的分析.TCR 测序的测序方式适应性免疫受体谱 (AIRR) 是一种适应性免疫受体谱.克隆追踪 克隆追踪 克隆追踪造血细胞 (干细胞) 移植 (HCST)免疫监测 免疫监测 免疫监测免疫复合 复合 免疫复合

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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