无翼平面细胞极性通路对于最佳活动依赖的突触可塑性至关重要
Carihann Dominicci-Cotto1,2, Mariam Vazquez2,3, Bruno Marie1,2,3
1Department of Anatomy and Neurobiology, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, United States.
Frontiers in synaptic neuroscience
|April 18, 2024
概括
非正规的平面细胞极性 (PCP) 途径对于无翼 (Wg) /Wnt信号在神经系统可塑性中至关重要. 扰乱PCP会扰乱Drosophila神经肌肉结节的活动依赖性突触可塑性 (ADSP).
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 发育生物学 发展生物学
背景情况:
- 无翼 (Wg) /Wnt信号对于神经系统的稳定性和物种间的可塑性至关重要.
- 在Drosophila神经肌肉结 (NMJ) 的活动依赖性突触可塑性 (ADSP) 是由Wg信号调节的.
- 规范性和非规范性Wg通路都会影响运动神经元ADSP.
研究的目的:
- 研究非正规平面细胞极性 (PCP) 途径在Wg介导的突触可塑性中的作用.
- 确定PCP信号是否对于运动神经元突触中的活动依赖性突触可塑性 (ADSP) 是必不可少的.
主要方法:
- 利用PCP特定的dsh等位基因来评估对新突触结构的影响.
- 研究了Rho GTPases在Dsh下游对调节形态变化的参与.
- 在ADSP中评估了Jun激酶和AP1 (Jun/Fos) 的必要性.
主要成果:
- 扰乱PCP通路显著破坏了ADSP.
- 在ADSP过程中,dsh等位基因影响了de novo突触结构的形成.
- 罗GTPases和Jun激酶,但不是AP1,对于ADSP相关的形态变化至关重要.
结论:
- 神经元PCP通路是Wg信号传输的关键组成部分,它支持ADSP.
- Wg激活可能涉及Rho GTPases和Jun kinase局部在突触,以调节ADSP期间的细胞骨动力学.
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