没有证据表明,在塔斯马尼亚魔鬼中,一种可传播的癌症已经从出现转移到流行
Maximilian R Stammnitz1, Kevin Gori1, Elizabeth P Murchison1
1Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Royal Society open science
|April 18, 2024
概括
这项研究挑战了关于塔斯马尼亚魔鬼面部瘤1 (DFT1) 的先前发现,这是一个威胁着魔鬼的传染性癌症. 这项研究表明,有缺陷的方法无效化了关于DFT1的先前结论.
科学领域:
- 保护生物学 保护生物学
- 进化生物学 进化生物学
- 癌症研究 癌症研究
背景情况:
- 塔斯马尼亚魔鬼因塔斯马尼亚魔鬼面部瘤1 (DFT1) 面临灭绝,这是一种独特的传染性癌症.
- 2020年的一项研究表明,DFT1已经从出现转向特有,其繁殖数为1.
研究的目的:
- 重新评估2020年帕顿等人报告的结论. 关于DFT1流行病学的研究.
- 评估用于建模DFT1.1的植物遗传学和植物动力学分析的有效性.
主要方法:
- 从DFT1瘤中重新检查基因组数据.
- 在参考研究中使用的突变调用和植物遗传学方法的批判性分析.
- 植物动力学建模审查.
主要成果:
- 在DFT1基因组数据中识别错误的突变调用.
- 在家族遗传树的构建和约会中证明了方法上的缺陷.
- 关于DFT1的流行病学参数的原始研究的结论是毫无根据的.
结论:
- 之前关于DFT1转向特有病的说法需要重新评估.
- 准确的基因组数据和强大的方法对于理解DFT1.1等传染性癌症至关重要.
- 需要进行进一步的研究,以准确确定DFT1.1的流行病状况和未来的发展轨迹.
更多相关视频
04:12Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
14.3K
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.8K
相关概念视频
The Evidence for Evolution
42.7K
Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
42.7K
Retroviruses
12.2K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.2K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Convergent Evolution
27.7K
Evolution shapes the features of organisms over time, ensuring that they are suited for the environments in which they live. Sometimes, selection pressure leads to the rise of similar but unrelated adaptations in organisms with no recent common ancestors, a process known as convergent evolution.
27.7K
Rous Sarcoma Virus (RSV) and Cancer
5.1K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.1K
What is Evolutionary History?
36.4K
Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
36.4K
