Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Telomeres and Telomerase

Telomeres and Telomerase

In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...

Replication in Eukaryotes

Replication in Eukaryotes

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

CRISPRi-Mediated Epigenetic Suppression of TERT Reduces Cell Growth in Non-Small-Cell Lung Cancer Cells.

Cells·2026

Same author

Long-term outcomes and late complications of intracranial germinoma: Implications for follow-up policy.

Neuro-oncology advances·2026

Same author

The Limited Role of Hypocortisolism in the Development of Delayed Postoperative Hyponatremia After Pituitary Surgery.

Pituitary·2026

Same author

Deep Learning for Survival Prediction in Glioblastoma: Time-dependent Model Interpretability Using MRI, Clinical, and Molecular Data.

Radiology. Artificial intelligence·2026

Same author

AI Augmented Confocal Laser Endomicroscopy for Rapid Intraoperative Diagnosis of Brain Tumors.

NPJ digital medicine·2026

Same author

Comparative Outcomes of Consolidation Strategies After R-MVP Induction in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System.

Cancer medicine·2026

Search research articles

相关实验视频

Updated: Jun 28, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

测定端粒长度的技术:一个方法论审查.

Hyeon Jong Yu¹, Yoon Hwan Byun², Chul-Kee Park¹

¹Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Computational and structural biotechnology journal

|April 18, 2024

概括

端粒长度对于染色体稳定至关重要,随着细胞分裂而缩短,影响衰老和疾病. 测量端粒长度为基因组健康和基因表达分析提供了关键的见解.

科学领域:

遗传学和分子生物学
细胞生物学细胞生物学
生物标志物研究生物标志物研究

背景情况:

端粒保护染色体末端并保持稳定性.
端粒缩短发生在细胞分裂时,与衰老和癌症等疾病有关.
除了细胞分裂之外的因素,例如氧化应激,也会影响端粒长度.

研究的目的:

审查和总结准确测量端粒长度的方法.
讨论各种端粒长度评估技术的优点和局限性.
突出测量端粒长度在了解衰老和疾病方面的重要性.

主要方法:

审查关于测量端粒长度技术的现有文献.
对端粒评估的不同方法进行比较分析.
讨论各种方法的技术方面和应用.

主要成果:

测量端粒长度存在多种方法,每种方法都有独特的优缺点.
准确的端粒长度评估是分析基因表达和表观遗传数据的基础.
端粒长度是衰老和与年龄有关的疾病的潜在生物标志物.

结论:

关键词:

基因技术基因技术序列分析序列分析南部血栓形成的情况端粒的长度端粒的长度

更多相关视频

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

相关实验视频

Last Updated: Jun 28, 2025

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

测量端粒长度对于理解基因组稳定性和疾病机制至关重要.
方法的选择取决于具体的研究问题和所需的准确性.
需要进一步的研究才能充分阐明端粒在健康和疾病中的作用.