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流行病对抗真菌使用的影响:有什么变化?

Vildan Avkan-Oğuz¹, Çaglar Irmak¹, Kağan Dağdeviren²

¹Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylül University School of Medicine, İzmir, Türkiye.

Infectious diseases & clinical microbiology

|April 18, 2024

概括

在COVID-19大流行期间,抗真菌药物的使用显著增加,特别是在血液学瘤学诊所. 这凸显了迫切需要新的抗真菌管理策略来管理不断增长的消费.

科学领域:

传染性疾病传染性疾病
药理学药理学是指药理学的学科.
医院管理局医院管理局

背景情况:

在COVID-19大流行期间,抗微生物和抗真菌管理计划的优先级被降低.
传染病专家的工作量增加导致咨询延迟.
初级医生越来越多地为住院患者提供抗真菌治疗.

研究的目的:

在COVID-19大流行期间评估抗真菌药物消费的变化.
为了比较大流行前和大流行期间的抗真菌使用情况.
确定在抗真菌使用中出现重大转变的特定临床领域.

主要方法:

使用的医院信息注册系统数据用于抗真菌药物使用.
使用世界卫生组织解剖治疗化学 (WHO ATC) 编码系统对药物进行分类.
计算的抗真菌消耗量以每100个睡日的定义每日剂量 (DDD/100个睡日).

主要成果:

在大流行期间,抗真菌消费量翻了一番 (7.43至18.03 DDD/100个睡日).
血液病瘤学-血液造血干细胞移植 (HSCT) 诊所的抗真菌使用量增加了2.5倍.
在血液学瘤学HSCT诊所中,脂质体安福特里辛B的消费量增加了四倍.

结论:

在重症监护室 (ICU) 和住院诊所观察到抗真菌消费的急剧增加.
这些发现强调了对一种新的抗真菌管理方法的迫切需要.
需要有效的策略来应对疫情后抗真菌药物使用量的增加.

关键词:

在 COVID-19 疫情中,氨基氨酸 B 是一种氨基氨酸.消费的抗真菌药物消费.抗真菌管理的管理.亚醇是一种这是一种 echinocandin.流行病是一种流行病.

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