伊斯坦布尔的新型SARS-CoV-2 Omicron变种;BA.2和BA.5的快速流行
Yeşim Tuyji-Tok1, Ebru Yücebağ1, Ayşe Betül Keleş1
1Department of Medical Microbiology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.
Infectious diseases & clinical microbiology
|April 18, 2024
概括
在土耳其,SARS-CoV-2的Omicron BA.2和BA.5变种显示出更高的传染性和病毒载量. 一种具有成本效益的PCR查方法有效地监测了这些迅速传播的Omicron变种.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 分子生物学分子生物学
背景情况:
- 土耳其的SARS-CoV-2第四波,从2021年12月开始,由于Omicron BA.2和BA.5变种,出现了峰值.
- 以前对土耳其的Omicron变种动态的理解是有限的.
研究的目的:
- 确定土耳其的Omicron BA.2和BA.5的流行率和与病毒载量相关的传播能力.
- 评估一种简单且具有成本效益的PCR查方法,用于变种监测.
主要方法:
- 使用了针对特定突变的两阶段RT-PCR方法 (NSP6 105-107del,尖端69-70del,尖端L452R).
- 周期值 (Ct) 值评估病毒载量和传播能力.
- 下一代测序 (NGS) 在代表性样本中证实了突变.
主要成果:
- 第一个BA.2病例是在2022年1月被发现的,其次是2022年5月的第一个BA.5病例.
- 与BA.1 (较低的Ct值) 相比,BA.2和BA.5的传播能力显著更高.
- 到2022年7月,BA.5变得占主导地位 (>85%的频率).
结论:
- 在BA.2和BA.5感染中,较高的病毒载荷表明传染性增加和不可避免的快速扩散.
- 开发的PCR查方法对于监测土耳其的Omicron变种是有效且具有成本效益的.
- 持续的测序研究对于早期检测新的SARS-CoV-2突变至关重要.
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