抗生素敏感性概况和Burkholderia cepacia复杂感染中的死亡率的关键决定因素
Yusuf Emre Özdemir1, Beyza Kaplan-Yapar1, Deniz Borcak1
1Department of Infectious Diseases and Clinical Microbiology, University of Health Sciences, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye.
鼻性Burkholderia cepacia复杂感染是一个重大威胁,特别是在ICU中. 增加的中性粒细胞/淋巴细胞比率,肌素,AST和前素,以及血小板数量的减少,可以预测不良结果.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 关键护理医学 关键护理医学
背景情况:
- 由于抗生素耐药性增加,Burkholderia cepacia复合体 (BCC) 在医疗保健环境中构成重大威胁.
- 体BCC感染与高死亡率有关,特别是在重症监护病房 (ICU).
研究的目的:
- 确定BCC感染的临床特征和抗菌敏感性概况.
- 为了确定患有医院内BCC感染的患者死亡率的预测因素.
主要方法:
- 这是一项单一中心的回顾性研究,从2018年至2022年对87名患有医院性BCC感染的患者进行了研究.
- 评估临床和微生物学数据,以确定14天和28天死亡率的预测因素.
- 使用多变量分析和ROC曲线分析来评估预测值的意义.
主要成果:
- 三甲胺-硫甲醇 (74.7%) 和莱沃素 (70.3%) 在BCC分离物中显示出最高的敏感率.
- 死亡率很高:14天 (41.3%),28天 (52.8%) 和住院 (64.3%).
- 中性细胞/淋巴细胞比率 (NLR),血小板计数,肌素和阿斯巴酸胺转移酶 (AST) 预测了14天死亡率. 甲素还预测了28天的死亡率.
结论:
- 在住院患者,特别是ICU患者中,BCC感染构成了重大挑战.
- 升高的NLR,AST,肌素,前素和血小板数量下降是BCC感染中临床结果不佳的潜在指标.
- 这些生物标志物可能有助于临床医生管理BCC感染并改进患者管理策略.
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