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患有胎儿生长不一致的同卵双胞胎在童年期间肺功能减弱:一个队列研究
Jip A Spekman1, Joël Israëls2, Ilja de Vreede2
1Neonatology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Centre, Leiden, the Netherlands.
EClinicalMedicine
|April 18, 2024
概括
在同卵双胞胎中,选择性胎儿生长限制 (sFGR) 显著损害了肺部发育,导致肺功能减弱和晚年呼吸风险增加.
科学领域:
- 儿科肺病学 儿科肺病学
- 胎儿医学 胎儿医学
- 遗传学 是一个遗传学.
背景情况:
- 胎儿生长限制 (FGR) 对肺部发育产生不利影响,增加了生命后期的呼吸系统问题.
- 对单身动物的FGR和肺功能研究受到各种因素的影响.
- 研究具有选择性FGR (sFGR) 的同卵双胞胎可以最大限度地减少遗传和母体混因素.
研究的目的:
- 评估sFGR对遗传相同双胞胎肺功能的影响.
- 确定子宫内生长限制是否会影响肺部发育和功能.
主要方法:
- 对具有sFGR (出生体重异常≥20%) 的同卵双胞胎进行了肺功能测试 (精神测量).
- 关键结果包括1秒内强制呼气量 (FEV1),强制生命能力 (FVC) 和一氧化碳扩散能力 (DLCO).
- 较小 (sFGR) 和较大的共同双胞胎之间的肺功能进行了比较.
主要成果:
- 分析了39对5至17岁的双胞胎.
- 与较大的双胞胎相比,较小的双胞胎在FEV1,FVC和DLCO方面的z分数明显较低.
- 即使考虑到肺体积减少,这些差异仍然存在.
结论:
- 具有sFGR的基因相同双胞胎显示肺体积和扩散能力减少.
- 不良的子宫内疾病会对肺部发育和功能产生负面影响.
- sFGR可能会导致晚年呼吸系统发病率增加.
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