FAPi PET/CT用于评估和可视化与肌肉炎相关的活跃间歇性肺病:一项前性观察试点研究
Kastriot Kastrati1, Thomas S Nakuz2, Oana C Kulterer2
1Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
EClinicalMedicine
|April 18, 2024
概括
肺部纤维细胞激活在患有异常性炎症性肌肉病和间歇性肺部疾病 (IIM-ILD) 的患者中升高. 这一发现表明FAPi PET/CT可以帮助评估IIM-ILD进展和患者风险.
科学领域:
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 间歇性肺病 (ILD) 是异常性炎症性肌肉病 (IIM) 的常见和严重并发症.
- 在IIM-ILD中组织重塑的体内证据有限.
- 纤维细胞激活是组织重塑和纤维化的关键过程.
研究的目的:
- 为了评估IIM患者肺部纤维细胞激活,使用68Ga标记的纤维细胞激活蛋白抑制剂 (FAPi) PET/CT.
- 为了比较IIM患者和没有ILD患者之间的FAPi摄入量,以及健康的对照.
- 为了将FAPi摄入量与疾病严重程度和进展标志物相关联.
主要方法:
- 涉及IIM患者和对照者的前性观察试点研究.
- FAPi PET/CT成像测量肺部FAPi吸收量 (SUVmax,SUVmean,TBR) 进行.
- 与高分辨率CT (HR-CT),肺功能测试 (PFT) 和临床评估的相关性分析.
主要成果:
- 与非ILD IIM患者和对照患者相比,IIM-ILD患者的肺FAPi吸收显著增加 (wlTBRmax,wlTBRmean).
- 渐进性ILD与稳定的ILD患者的FAPi摄入量较高.
- 在FAPi摄入量和HR-CT发现,呼吸系统症状严重程度 (NYHA) 之间存在强烈的相关性,以及与FVC和DLCO的反相关性.
结论:
- 在IIM-ILD.中,FAPi PET/CT显示纤维细胞活化增加.
- 肺FAPi积累强度与ILD进展相关.
- FAPi PET/CT显示出作为IIM相关肺部疾病风险分层的非侵入性工具的潜力.
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