作为肥胖症治疗方法的减肥手术之前的微生物群动态:综合性综述
Ana Karina Zambrano1, Elius Paz-Cruz1, Viviana A Ruiz-Pozo1
1Facultad de Ciencias de la Salud Eugenio Espejo, Centro de Investigación Genética y Genómica, Universidad UTE, Quito, Ecuador.
Frontiers in nutrition
|April 18, 2024
概括
腹腔外科手术显著改变肠道微生物群,影响肥胖治疗中的代谢健康. 了解这些微生物变化是预测结果和制定个性化肥胖管理策略的关键.
科学领域:
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
- 手术干预 手术干预
背景情况:
- 肥胖是一种复杂的代谢障碍,需要有效的治疗策略.
- 腹腔外科手术,包括Roux-en-Y胃绕道 (RYGB) 和袖子胃切除术 (SG),是病态肥胖的主要干预措施.
- 肠道微生物群在宿主新陈代谢和能量平衡中起着至关重要的作用.
研究的目的:
- 审查减肥手术,肠道微生物群和肥胖中的代谢健康之间的关系.
- 为了探索不同的减肥手术如何影响微生物的组成和功能.
- 了解微生物群衍生代谢物和激素对手术后代谢结果的影响.
主要方法:
- 审查关于减肥手术结果和肠道微生物群分析现有文献.
- 在RYGB和SG等程序后,分析细菌多样性和丰度的变化.
- 检查微生物代谢物的作用,如胆汁酸和短链脂肪酸,以及内激素 (例如GLP-1).
主要成果:
- 腹腔外科手术,特别是RYGB和SG,导致肠道微生物群的多样性和丰度发生显著变化.
- 手术后的变化包括大肠杆菌的增加,与脂肪质量和瘦素相反相关.
- 微生物群衍生化合物 (胆酸,SCFA) 和增强的隐素分泌 (GLP-1) 被调节,影响新陈代谢.
结论:
- 减肥手术后肠道微生物群的改变是改善代谢健康的重要组成部分.
- 了解这些微生物变化对于预测患者的结果和优化肥胖治疗至关重要.
- 基于微生物群调节的有针对性的干预措施对未来的肥胖管理具有前景.
相关概念视频
Anatomy of the Intestines
71.8K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
71.8K
Bacterial Flora of the Large Intestine
435
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
435
What is Monogastric Digestion?
71.1K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.1K
Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145


