定期有氧运动对认知功能,抑郁程度和神经营养因子的调节作用的影响:年轻和中年样本中的前性队列研究
Lingming Kong1, Liqin Miu2, Wenwei Yao2
1Mental Health Research Center, No. 904th Hospital, Changzhou, Jiangsu, 213003, People's Republic of China.
Risk management and healthcare policy
|April 18, 2024
概括
定期的有氧运动可以提高认知功能,并通过增加脑衍生神经营养因子 (BDNF) 和质细胞衍生神经营养因子 (GDNF) 水平来降低抑郁症. 这为预防轻度认知障碍 (MCI) 和抑郁症 (DD) 提供了科学基础.
科学领域:
- 神经科学是一个神经科学.
- 运动生理学 运动生理学
- 心理健康 心理健康
背景情况:
- 轻度认知障碍 (MCI) 和抑郁障碍 (DD) 是与生活方式因素相关的全球健康问题.
- 神经营养增长因子在大脑健康和情绪调节中起着至关重要的作用.
研究的目的:
- 为了检查定期有氧运动对认知功能和抑郁症的影响.
- 调查神经营养因子 (BDNF,GDNF) 在调解这些影响中的作用.
- 为以运动为基础的预防MCI和DD提供科学基础.
主要方法:
- 招募了160名参与者 (80名健身中心成员,80名社区居民).
- 使用可重复电池评估神经心理状态 (RBANS) 评估认知功能.
- 用患者健康问卷 (PHQ-9) 测量抑郁症状.
- 通过ELISA通过脑衍生神经缩因子 (BDNF) 和质细胞系衍生神经缩因子 (GDNF) 的量化血清水平.
主要成果:
- 与对照组相比,炼组的RBANS分数 (不包括视觉空间能力) 和PHQ-9分数较低.
- 在运动组中观察到BDNF和GDNF水平升高.
- RBANS得分与BDNF和GDNF正相关,而PHQ-9得分与BDNF和GDNF负相关.
- BDNF预测了59.90%的RBANS变异;GDNF预测了12.30%的PHQ-9变异.
结论:
- 定期的有氧运动可以提高认知功能,缓解抑郁症状.
- 这些改善与BDNF和GDNF水平的增加有关.
- 通过对神经营养因子的影响,有氧运动显示出预防认知衰退和抑郁症的潜力.
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