没有调解男性饮食炎症和血清克洛托水平之间的相关性:来自NHANES数据库的见解
Siyu Du1,2,3, Jieyi Zhao4, Xinyue Chou5
1Department of Reproductive Medical Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in endocrinology
|April 18, 2024
概括
饮食中的炎症会影响男性的血清Klotho水平,自由素指数 (FAI) 调解了这种关系. 在调整后,和自由没有显示出显著的调解效应.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 衰老研究研究 衰老研究
背景情况:
- 血清克洛托 (S-Klotho) 对于抗衰老至关重要,低食炎症指数 (DII) 饮食与男性延迟衰老有关.
- 丸激素作为DII和S-Klotho之间的中间体的潜在作用尚未被探索.
研究的目的:
- 在男性中调查DII和S-Klotho之间的丸激素的潜在因果关系.
- 检查 (TT),自由 (FT) 和自由素指数 (FAI) 对DII-S-Klotho关系的调解作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) 男参与者的数据 (2013-2016).
- 使用调解分析来评估DII,S-Klotho和雄激素水平 (TT,FT,FAI) 之间的关系,通过三种模型进行共变量调整.
主要成果:
- 在DII和S-Klotho水平之间发现了显著的反相关性 (模型1:c = -14.78,p = 0.046).
- 在共变性调整后, (TT) 和自由 (FT) 没有显著的调解.
- 自由雄激素指数 (FAI) 连续且显著地调节了DII-S-Klotho关系,即使经过调整 (模型2:ab = 3.2,p = 0.004;模型3:ab = 3.15,p = 0.026).
结论:
- 丸激素和自由丸激素在男性的共同控制后不会调解DII-S-Klotho关联.
- 自由雄激素指数 (FAI) 显著调解了男性的饮食炎症和血清Klotho之间的关系,需要进一步调查.
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