在结核病流行环境中持续的Mycobacterium结核病生物气溶释放
Ryan Dinkele1,2, Sophia Gessner1,2, Benjamin Patterson3
1UCT Molecular Mycobacteriology Research Unit, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, 7925, South Africa.
medRxiv : the preprint server for health sciences
|April 18, 2024
概括
通过气溶释放的结核菌菌 (Mtb) 在社区中很常见,即使没有活跃的结核病. 这一发现挑战了关于结核病传播的传统观点,表明广泛的Mtb流产发生在被诊断的疾病之外.
科学领域:
- 微生物学与传染病的研究
- 公共卫生和流行病学
背景情况:
- 传统的理解认为,症状性结核病 (TB) 疾病对于Mycobacterium tuberculosis (Mtb) 传播是必要的.
- 以前的研究表明,没有结核病诊断的个体释放了Mtb气溶,这挑战了传播活动病理的必要性.
- 亚临床Mtb脱落在社区级传播动态中的作用在很大程度上仍未被探索.
结论:
- 这项研究需要在了解Mtb传播方面进行范式转变,强调了超出症状性疾病的常见气溶泄露.
- 广泛的Mtb释放可能解释了在结核病流行地区追踪传播网络的困难.
- 需要进一步的研究,以了解亚临床Mtb脱落对结核病控制策略的影响.
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