导航治疗困境:反抗性和多种并发病的负担
Priya Garg1, Kshitiz Lakhey2, Nishtha Mishra1
1Dermatology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Cureus
|April 18, 2024
概括
严重的自身免疫性皮肤疾病 - - 皮虫 (Pemphigus vulgaris) 在一位35岁的女性身上带来了复杂的挑战. 尽管进行了各种治疗,但包括深静脉血栓在内的并发症导致了致命的结局.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 庞菲古斯 (Pemphigus vulgaris) 是一种慢性自身免疫性水泡性疾病,其向的目标是desmogleins.
- 开始通常发生在40岁左右,但这种情况突出了潜在的变化.
研究的目的:
- 呈现出复杂的pemphigus vulgaris病例,具有多种并发症和治疗并发症.
- 为了评估在严重的pemphigus vulgaris病例中的伤口愈合策略.
主要方法:
- 临床诊断和组织病理学确认的pemphigus vulgaris.
- 治疗包括皮质类固醇,mycophenolate mofetil和试图输注利图西马布.
- 并发症的管理:深静脉血栓塞 (DVT) 预防,败血症治疗,血液透析,治疗性血交换 (TPE).
- 伤口护理包括原蛋白,状银,泡敷料,过氧化和氨酸酶.
主要成果:
- 氨酸酶在伤口病变中显示出相当大的改善.
- 患者患有严重的败血症,急性功能衰竭和肺血栓塞栓症 (PTE).
结论:
- 这一案例凸显了在患有并发症的患者中,与pemphigus vulgaris相关的严重并发症和治疗挑战.
- 尽管进行了干预,但患者因DVT的次要肺血栓塞栓症而死亡.
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