时间可追溯的微标签用于防伪和食品和药物的安全分发
Cheolheon Park1, Yunjin Jeong1, Huiran Yeom2
1Bio-MAX Institute, Seoul National University, Seoul 08826, Republic of Korea.
Biomicrofluidics
|April 18, 2024
概括
研究人员开发了编码的微粒用于药物跟踪和安全. 这些微粒可预见地降解,揭示编码信息以确保药品质量并防止改.
科学领域:
- 材料科学 材料科学 材料科学
- 制药技术 制药技术 制药技术
- 分析化学 分析化学
背景情况:
- 制药供应链面临着假冒药物和质量下降的挑战.
- 目前用于追踪和确保药物的真实性的方法往往是不够的.
- 需要创新的解决方案来实时监测药品完整性.
研究的目的:
- 开发和表征环保的编码微粒,以提高药品的跟踪和安全性.
- 设计具有可降解掩盖层的微结构,以控制信息释放.
- 评估这些微粒对于实时监测药品保质期和真实性的潜力.
主要方法:
- 使用无面膜光刻法,以设计具有30微米可降解掩盖层的微粒.
- 在微观结构中嵌入了对环境敏感的编码微粒.
- 在酸盐缓冲盐水中使用红色光强度在144小时内监测掩盖层的受控溶解.
主要成果:
- 在生理条件下,被证明可预测的掩盖层降解.
- 通过对光强度的定量分析证实了微粒子完整性.
- 成功地从微粒中提取了编码信息,将降解与时间相关联.
结论:
- 开发的微粒为实时制药监测提供了强大的方法.
- 掩盖层的受控降解作为药物的保质期指标.
- 这项技术通过阻止改和确保产品真实性来提高药品安全性.
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