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患有慢性肠病症的猫的治疗成功与便中calprotectin度的下降有关.

Romy M Heilmann1, Denise S Riggers1, Isla Trewin2

  • 1Department for Small Animals, College of Veterinary Medicine, University of Leipzig, Leipzig, Germany.

Frontiers in veterinary science
|April 18, 2024
PubMed
概括

便calprotectin是一种有希望的非侵入性生物标志物,用于监测猫类慢性肠道病变 (FCE). 治疗后度显著下降,与临床改善和疾病严重程度相关.

关键词:
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科学领域:

  • 兽医医学 兽医医学 兽医医学
  • 胃肠病学 胃肠病学
  • 生物标志物发现发现

背景情况:

  • 猫类慢性肠病 (FCE) 存在诊断和监测方面的挑战.
  • 需要非侵入性生物标志物来评估FCE的治疗反应和疾病进展.
  • 便中的calprotectin是肠道炎症的潜在标记物.

研究的目的:

  • 在治疗前和治疗后评估患有FCE的猫的便calprotectin度.
  • 评估便calprotectin水平与临床严重程度 (FCEAI) 和组织病理学发现之间的相关性.
  • 确定便calprotectin作为替代生物标志物用于FCE治疗监测的实用性.

主要方法:

  • 便中的calprotectin在17只患有FCE的猫和18只健康的对照猫中进行了测量.
  • 在治疗前和治疗后 (免疫调节和/或饮食干预) 收集样本.
  • 使用猫类慢性肠病活动指数 (FCEAI) 评估临床严重程度;一些猫接受了超声波和活检.

主要成果:

  • 在FCE猫中,便中calprotectin度在治疗前明显高于治疗后和对照组.
  • 便calprotectin水平与FCEAI得分和十二指甲/近端关病理相关.
  • 在猫中观察到便calprotectin水平降低,临床改善或缓解.

结论:

  • 便calprotectin是一种有价值的非侵入性生物标志物,用于评估疾病严重程度和监测猫类慢性肠病的治疗反应.
  • 便calprotectin的变化反映了临床改善,与病理发现相关.
  • 需要进行进一步的纵向研究,以调查便calprotectin与粘膜愈合和临床反应有关.