长非编码RNA小核核RNA宿主基因作为肝细胞癌的预后分子生物标志物:一个元分析
Meng Huang1, Zhiwen Zhao1, Lihua Yang1
1Medical Center for Digestive Disease, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Cancer medicine
|April 18, 2024
概括
在肝细胞癌 (HCC) 中,高调小核细胞RNA宿主基因 (SNHGs) 与预后不佳相关. 更高的SNHG表达与更短的生存期和晚期疾病有关,这表明SNHG是潜在的HCC生物标志物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 小核核RNA宿主基因 (SNHGs) 的异常表达在肝细胞癌 (HCC) 中越来越多.
- 在HCC中SNHG表达的预后价值仍然不清楚.
- 这一元分析旨在澄清SNHG表达和HCC预后之间的关联.
研究的目的:
- 确定长非编码RNA (lncRNA) SNHG在肝细胞癌 (HCC) 的预后意义.
- 评估SNHG表达水平与HCC患者临床病理特征之间的关联.
主要方法:
- 在Embase,科学网,PubMed和Cochrane图书馆的系统文献搜索,截至2024年2月.
- 对25项研究的元分析,其中包括2314名HCC患者.
- 使用危险比率 (HRs) 和95%置信区间 (CI) 评估预后意义;使用几率比率 (ORs) 评估临床病理特征.
主要成果:
- 过度表达的SNHG与较大的瘤大小,多个瘤,较差的组织学等级,淋巴转移,静脉入侵,晚期瘤阶段,门静脉瘤血栓形成 (PVTT) 和高的α-fetoprotein (AFP) 相关.
- 在SNHG表达和乙型肝炎病毒 (HBV) 感染或肝硬化之间没有发现显著的关联.
- 较高的SNHG表达与较短的整体存活 (OS),无复发存活 (RFS) 和无疾病存活 (DFS) 相关联.
结论:
- 在HCC中SNHG的升级与不利的预后因素有关.
- SNHG表达与较短的OS,RFS和DFS相关.
- SNHGs显示出作为肝细胞癌的预后生物标志物的潜力.
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