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动脉硬性损伤中的居民记忆T细胞与减少巨细胞含量和增加损伤稳定性有关

Maaike J M de Jong¹, Marie A C Depuydt¹, Frank H Schaftenaar¹

¹Division of Biotherapeutics, Leiden Academic Centre for Drug Research, Leiden University, the Netherlands (M.J.M.d.J., M.A.C.D., F.H.S., K.L., D.M., J.K., I.B., B.S.).

Arteriosclerosis, thrombosis, and vascular biology

|April 18, 2024

概括

组织内存T (T_RM) 细胞在动脉样硬化病变中被发现,可以增加病变的稳定性. 在小鼠模型中,这些表达CD69和CD49α的T_RM细胞减少巨细胞并增加原蛋白.

科学领域:

免疫学免疫学免疫学
心血管研究研究心血管研究
细胞生物学细胞生物学

背景情况:

组织内存T (T_RM) 细胞对屏障部位的免疫非常重要.
T_RM细胞表达CD69,Hobit和Blimp-1,并与炎症状况有关.
动脉内心中CD69+ T细胞的存在表明T_RM细胞在动脉样硬化病变发生过程中发挥了作用.

研究的目的:

研究人类和小鼠动脉样硬化病变中的T_RM细胞的存在和功能.
为了确定T_RM细胞是否有助于动脉样硬化的发展和进展.

主要方法:

人类动脉样硬化病变的单细胞RNA测序,以识别T_RM细胞特征.
利用小鼠模型追踪动脉样硬化病变中的霍比特表达T_RM细胞.
采用了一种骨髓移植模型,用T_RM缺乏的小鼠 (Hobit^KO/CREBlimp-1^flox/flox) 食西方饮食,以评估T_RM细胞在动脉生成中的功能.

主要成果:

人类动脉样硬化病变含有具有T_RM基因特征的T细胞,与已知的T_RM细胞聚集在一起.
以CD69和CD49α表达为特征的霍比特表达T_RM细胞在小鼠动脉样硬化病变中得到证实.
这种T_RM细胞子集通过减少内伤性巨细胞和增加原蛋白含量来调节病变组成.

结论:

在动脉样硬化病变中,T_RM细胞是一个小群体,通过CD69和CD49α表达来识别.
在Hobit和Blimp-1淘汰赛小鼠模型中,T_RM细胞与增加动脉样硬化病变稳定性有关.
T_RM细胞影响动脉样硬化病变的组成,影响巨细胞含量和原沉积.

关键词:

这是T-淋巴细胞.过敏和免疫学的过敏和免疫学.动脉样硬化动脉样硬化记忆T细胞记忆T细胞转录因子是一种转录因子.

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