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氧气自给的 perfluorocarbon-modified 微粒用于增强癌症光动力学疗法和铁化

He Ren¹, Minchao Hao¹, Gengqi Liu¹

¹School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering (Ministry of Education), Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300350, P.R. China.

ACS applied bio materials

|April 18, 2024

概括

这项研究开发了一种提供氧气的纳米平台 (Ce6-Sor@PFC-F127) 用于联合光动力学疗法 (PDT) 和铁灭癌症治疗. 这种方法可以在缺乏氧气的环境中增强药物输送和杀死瘤细胞.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

光动力学疗法 (PDT) 和铁化对瘤治疗有希望,但由于瘤微环境的缺氧和药物输送不良,这些疗法受到限制.
治疗药物的有效细胞内输送到瘤细胞仍然是最大限度地提高治疗疗效的挑战.

研究的目的:

开发一种新的氧气自供纳米平台,用于增强光动力学疗法 (PDT) 和铁.
为了改善光敏感剂和铁灭诱导剂在瘤细胞中的联合递送,用于协同治疗癌症.

主要方法:

合成的完全化碳 (PFC) 修饰的Pluronic F127 (PFC-F127) 作为药物载体.
使用PFC-F127纳米平台同时提供e6 (Ce6) 和索拉芬尼 (Sor),产生Ce6-Sor@PFC-F127.
利用低压盐水技术提高货物封装效率.
在小鼠瘤模型中评估了纳米平台的有效性.

主要成果:

该PFC-F127纳米平台有效地输送氧气,增强PDT和铁亡.
细胞表面的水性增加导致癌细胞内细胞增强.
组合疗法在体内显著抑制了瘤生长.
证明了瘤细胞的放大内细胞和细胞毒性.

结论:

Ce6-Sor@PFC-F127是一种多功能纳米平台,用于共同输送氧气,光敏感剂和铁灭诱导剂.
这种方法为克服瘤缺氧和改善癌症治疗结果提供了一个有希望的策略.
开发的纳米平台在协同治疗癌症方面具有显著的潜力.

关键词:

铁性化 (ferroptosis) 是一种米塞尔 (Micelle) 是一个小女孩.输送氧气输送氧气提供氧气一个完全化碳.光动力学疗法是一种光动力学疗法.

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