在非常早产婴儿的呼吸道和胸壁机制
Benjamin Stoecklin1,2,3, Chiara Veneroni4, Y Jane Choi1,5
1School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia.
Journal of applied physiology (Bethesda, Md. : 1985)
|April 18, 2024
概括
静态呼吸系统合规性 (Crs),肺合规性 (CL) 和胸壁合规性 (Ccw) 是非常早产婴儿的特征. 患有支气管肺功能障碍 (BPD) 的婴儿显著减少了Crs,CL和Ccw.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 呼吸系统生理学 呼吸系统生理学
背景情况:
- 对于早产婴儿的胸壁 (Ccw) 的静态合规数据有限.
- 了解呼吸系统合规性 (Crs) 的组成部分对于管理新生儿呼吸困扰至关重要.
研究的目的:
- 描述静态肺 (CL) 和胸壁 (Ccw) 在36周月经后年龄 (PMA) 非常早产婴儿的合规性.
- 确定CL和Ccw对Crs的相对贡献.
- 调查支气管肺功能障碍症 (BPD) 对这些符合性和呼吸变量的影响.
主要方法:
- 在赫林格-布鲁尔反射呼吸暂停期间同时测量气道开口压力,食道压力和潮体积.
- 计算潮呼吸变量,呼吸道阻力 (R),动态肺部顺应 (CL,dyn),吸气容量 (IC),Crs,CL和Ccw.
- 使用多重呼吸冲洗技术 (FRCmbw) 评估功能剩余容量 (FRC).
- 所有变量都根据体重进行了调整.
主要成果:
- 与没有BPD的婴儿相比,患有BPD的婴儿 (n=11) 的Crs/kg,CL/kg和Ccw/kg显著降低.
- 在不同组中,Ccw/CL比率是相似的.
- 在患有BPD的婴儿中,功能残余容量 (FRCmbw/kg) 和吸气容量 (IC/kg) 降低.
结论:
- 患有BPD的婴儿减少了静态呼吸系统,肺部和胸壁的遵守.
- 患有BPD的婴儿的遵守率下降有助于降低功能残留能力和吸气能力.
- 这项研究提供了关于早产婴儿在表面活性剂后时代的静态呼吸机制的新数据,特别是关于BPD的影响.
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