禁食新陈代谢的变化是否存在性别差异?
Louise Bradshaw1,2, Jariya Buniam1,2,3, James A Betts1,2
1Centre for Nutrition, Exercise and Metabolism, University of Bath, Bath, United Kingdom.
Journal of applied physiology (Bethesda, Md. : 1985)
|April 18, 2024
概括
女性在性激素的日常变化较大,但在关键的代谢标志物 (如葡萄糖或休息代谢率) 中没有变化. 这表明,将女性纳入代谢研究不会显著增加个体内变异性.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 人类生理学 人类生理学
背景情况:
- 男性经常表现出更大的跨个体差异跨特征.
- 绝经前的女性在性激素中表现出显著的个体内变异,这可能会影响代谢研究的表现.
- 了解代谢参数的差异对于准确的研究设计至关重要.
研究的目的:
- 为了研究性差异在断食血代谢物,休息代谢率 (RMR) 和身体质量的个体间和个体内变异.
- 为了确定雌性是否在代谢研究中引入更大的个体内变异性.
主要方法:
- 对来自七项交叉研究的数据进行了二次分析.
- 测量了禁食血代谢物,休息代谢率 (RMR) 和体重.
- 分析了男性和女性之间的个体间和个体内差异.
主要成果:
- 女性在17β-雌激醇和孕激素中表现出更高的个体内变化.
- 性别之间对葡萄糖,胰岛素,乳酸,甘油三或化脂肪酸的个体内变异性没有显著差异.
- 对于RMR或人体质量的个体内变异性没有任何有意义的差异.
- 男性在RMR中显示出更高的个体间差异.
结论:
- 数据不支持与男性相比,女性的绝大多数禁食代谢变量,RMR或体重的更大个体内变化.
- 在适当的协议下,将女性纳入代谢研究,不太可能引入实质性的个体内差异.
- 在荷尔蒙波动中的性别差异并不一定转化为研究环境中的代谢变化.
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