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多传感器原木平台:一种可定制的系统,用于在3D模型中获得时空精确的功能读数

Noam Rahav¹, Denise Marrero^2,3,4, Adi Soffer⁴

¹School of Neurobiology, Biochemistry and Biophysics, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|April 18, 2024

概括

一个新的原创灵感平台可以在3D生物打印组织中精确地放置传感器,以获得功能性读取. 这种多传感原木平台 (MSOP) 克服了当前生物打印技术的局限性,用于先进的组织建模.

科学领域:

生物医学工程生物医学工程
组织工程是组织工程.
生物制造的生物制造

背景情况:

3D生物打印使得体外组织模型具有原生形态和功能.
从生物打印组织中获得功能性读数是具有挑战性的,因为传感器放置的困难.
在传感器上直接进行生物打印会干扰打印机头.

研究的目的:

引入一个多感应原木平台 (MSOP),以改善3D生物打印组织的功能评估.
为了能够精确地将电极插入预制的3D组织结构中.
为了克服目前生物打印中传感器集成的局限性.

主要方法:

开发了一个灵感来自于原创的平台,可以围绕3D组织结构折叠.
使用计算机辅助设计来定制电极放置.
将MSOP与商用多电极阵列 (MEA) 系统集成.
证明了用于记录神经元活动和测量内皮质屏障功能的电极集成.

主要成果:

通过使用集成的3D MEA电极在3D神经血管单元模型中成功记录了神经元的电活动.
通过MSOP内的基于阻抗的传感器测量了内皮膜屏障功能.
通过测量大脑器官中的神经元活动来展示平台的多功能性.

结论:

该MSOP促进精确的,非侵入性的传感器集成在3D生物打印模型.
这个平台增强了复杂组织结构的功能特征.
该MSOP有望推进体外组织建模和药物查.

关键词:

3D MEA 是一个3D MEA.生物打印是一种生物打印技术.奥里加米是指原始的传感器集成传感器集成传感器集成

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