在怀孕并发症之前和之后的炎症,代谢和内皮细胞生物标志物
Baiyang Sun1,2, Erica P Gunderson3,4, Marnie Bertolet1
1School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, United States.
患有妊娠糖尿病或高血压疾病的妇女表现出更高的孕前炎症和代谢功能障碍,在分娩后持续存在. 过早分娩与不同的炎症和代谢生物标志物变化有关,这表明有不同的心血管疾病风险.
科学领域:
- 心血管疾病风险因素 心血管疾病风险因素
- 怀孕并发症 怀孕并发症
- 生物标志物的分析分析.
背景情况:
- 孕期糖尿病 (GDM),妊娠高血压疾病 (HDP) 和早产 (PTB) 的妇女面临心血管疾病 (CVD) 的风险增加.
- 潜在的潜在因素包括妊娠前的炎症,代谢障碍和内皮功能障碍.
研究的目的:
- 调查与GDM,HDP和PTB相关的孕前和孕后生物标志物概况.
- 了解这些怀孕结果与心血管风险标志物之间的关系.
主要方法:
- 分析了年轻成年人冠状动脉风险发展研究 (1985-2011) 中1238名女性的数据.
- 根据结果对2215例出生进行分类:无并发症,GDM,HDP和PTB.
- 重复测量对变异的分析,以评估妊娠前期,妊娠后期和生物标志物的变化 (hsCRP,瘦素,子蛋白,ICAM-1),经过调整以考虑混因素.
主要成果:
- 孕期GDM和孕期HDP组呈现较高的孕前hsCRP,瘦素和较低的脂肪内素,在孕后持续存在.
- 通过对体重指数 (BMI) 进行控制,这些特征在很大程度上减弱了,除了在GDM中较低的孕前皮质素.
- 没有GDM/HDP的PTB与较低的孕前hsCRP和ICAM-1相关,并且从怀孕前到怀孕后更大程度上增加了瘦素.
结论:
- 怀孕前的炎症和代谢功能障碍,可能与更高的BMI有关,有助于GDM和HDP.
- PTB可能涉及妊娠后不良的代谢变化.
- 在PTB中独特的内皮细胞生物标志物配置值得进一步调查心血管疾病风险.
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