尿道代谢概况揭示了患有喘的儿童的代谢途径
Sainan Jiang1, Yiting Zhou1, Jianlong Gao2
1Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
概括
儿童的喘与尿液中创伤性酸和 dodecanedioic 酸水平较低有关. 这些发现表明,α-烯酸代谢可能在儿童喘发育中起作用.
科学领域:
- 儿科肺病学 儿科肺病学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 全球喘患病率正在上升,这对公众健康构成了重大挑战.
- 喘的复杂和异质性质使理解其致病机制变得复杂.
- 代谢学提供了一种新的方法来研究喘病原性.
研究的目的:
- 为了研究患有喘的儿童的尿路代谢概况.
- 为了确定特定的代谢途径参与儿童喘的发病.
主要方法:
- 基于液态染色体质谱法 (LC-MS) 的代谢分析.
- 30名喘儿童和10名健康对照儿童的尿液代谢概况比较.
- 在数据分析中对隐性结构差异分析 (OPLS-DA) 的直角投影.
主要成果:
- 在喘儿童和健康对照人群之间观察到显著的代谢差异.
- 确定了三种差异性代谢物:创伤酸,十二二氧化酸和葡萄糖.
- 在喘儿童的尿液中发现了较低水平的创伤酸和 dodecanedioic 酸.
结论:
- 在喘儿童和健康个体之间,尿道代谢概况显著不同.
- 阿尔法-烯酸代谢途径与喘的发病有关.
- 代谢分析为儿童喘的生物化学基础提供了洞察力.
相关概念视频
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
277
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
277
Asthma: Pathogenesis and Management
391
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
391
Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K


