酒精消费对代谢功能障碍相关脂肪肝疾病发展和缓解的影响:一个纵向队列研究
Masahiro Sogabe1,2, Toshiya Okahisa1,2, Miwako Kagawa2
1Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Tokushima City, Tokushima, Japan.
European journal of clinical investigation
|April 18, 2024
概括
饮酒对男性和女性的代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的发展有不同的影响. 建议减少饮酒,以预防肝纤维化,即使在MAFLD缓解后也是如此.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 公共卫生 公共卫生
背景情况:
- 酒精消费与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 的发展和缓解之间的关系尚未完全理解.
- 调查酒精摄入量与MAFLD之间的纵向关联对于公共卫生指南至关重要.
研究的目的:
- 检查酒精摄入量与MAFLD的发展和缓解之间的纵向关联.
- 为了确定酒精消费模式是否影响MAFLD在一个大队列中的进展或逆转.
主要方法:
- 一项观察性队列研究涉及6349名患者,他们在2013年至2021年期间进行了两次以上的健康检查.
- 用通用估计方程来分析酒精摄入量变化与MAFLD状态之间的纵向关联.
主要成果:
- 男性的MAFLD发病率为20.4%,女性为9.1%,缓解率分别为5.1%和4.7%.
- 具体的每周酒精消费水平是男性 (每周0.1-69.9克) 和女性 (每周≥280克) 发展MAFLD的重要因素.
- 酒精消费对两性中MAFLD缓解没有显著影响,但减少摄入量与显著纤维化得分的男性缓解有关.
结论:
- 酒精摄入对MAFLD发展和缓解的影响因性别和消费水平而异.
- 酒精消费对MAFLD缓解没有好处,可能会加剧肝纤维化.
- 建议减少或停止饮酒,以预防肝纤维化,即使在获得MAFLD缓解的个体中也是如此.
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