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用于治疗的欧性溶液:对治疗性深层欧性溶剂 (TheDES) 的全面审查
Sudhanshu Kalantri1, Amisha Vora1
1Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, India.
Drug development and industrial pharmacy
|April 18, 2024
概括
深度浸泡溶剂 (DES) 增强药物输送和溶解性. 本次审查强调了它们的优势,包括低毒性和生物降解性,用于制药应用.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 深层阳性溶剂 (DES) 是通过混合键供体 (HBD) 和键受体 (HBA) 形成的.
- DES具有独特的特性,如低毒性,生物降解性和生物相容性.
- 这些溶剂在增强药物溶解性,透性和输送方面显示出潜力.
研究的目的:
- 在制药应用中审查深层欧特基溶剂 (DES) 的优势.
- 突出DES在改善难溶性活性药物成分 (API) 输送方面的作用.
主要方法:
- 进行了系统的文献审查.
- 从索引数据库中确定了相关论文.
- 研究是根据重要性,质量和方法进行选择的.
主要成果:
- 确定了各种DES配方,其中的组件作为载体或API.
- DES在提高各种API的溶解性和输送方面表现出有效性,包括NSAID和抗真菌药物.
- 审查证实了DES在药物交付药物研究中的重大进步.
结论:
- 深层欧特基溶剂 (DES) 为先进的药物配方和输送系统提供了一个有前途的平台.
- 它们的有利性质,包括低毒性和生物降解性,支持它们在各种治疗应用中的使用.
- 使用DES是克服与难溶性药物相关的挑战的重要一步.
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