发育阶段和感染状态可能会影响大鼠前列腺中药物分布
Ziyang Xu1, Lianzhan Sun1, Chang Yin1
1Department of Pharmacy, Shanghai Changhai Hospital, the First Affiliated Hospital of Naval Medical University, Shanghai, China.
概括
药物透到前列腺对于治疗炎症至关重要. 前列腺成熟和感染显著影响血前列腺屏障 (BPB) 的抗生素水平.
科学领域:
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
背景情况:
- 抗菌剂往往无法有效治疗前列腺炎症,原因是透能力差.
- 血前列腺屏障 (BPB) 对药物输送到前列腺上皮质提出了重大挑战.
- 影响前列腺抗微生物疗效的因素尚不完全理解.
研究的目的:
- 为了研究levofloxacin和cefradine在老鼠的前列腺和血中的药理学概况.
- 评估前列腺成熟和感染对跨血前列腺屏障的药物度的影响.
- 阐明影响抗微生物药物运输和前列腺中的疗效的因素.
主要方法:
- 在不同老鼠群体 (成年,青春期和感染者) 中对levfloxacin和cefradine的药理动力学分析.
- 从前列腺和静脉收集透析剂,以测量药物度.
- 计算前列腺/血度比 (AUC0-t和AUC0-∞) 以评估药物透率.
主要成果:
- 前列腺和血中的抗菌剂度在20分钟后达到峰值,然后下降.
- 列沃素的前列腺/血AUC比为0.53至0.97之间,而塞弗拉丁则从0.30至0.85之间.
- 与成年人相比,青春期老鼠的药物透率较低,与青春期老鼠相比,感染老鼠的药物透率较高.
结论:
- 前列腺成熟度会影响药物穿越血前列腺屏障的能力.
- 前列腺感染可以破坏血前列腺屏障,可能提高药物的透性.
- 了解这些因素对于优化前列腺炎症抗生素治疗至关重要.
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