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在高海拔实地研究期间的SARS-CoV-2传播

Mirjam Grimm^1,2, Lucie Ziegler^1,2, Annina Seglias^1,2

¹Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland.

High altitude medicine & biology

|April 18, 2024

概括

在吉尔吉斯斯坦的高海拔临床研究中,严格的COVID-19预防措施显著降低了严重急性呼吸综合征冠状病毒2型 (SARS-CoV-2) 传播. 该研究发现,参与者和工作人员的SARS-CoV-2发病率低于一般人群.

科学领域:

高海拔医学高海拔医学
传染病流行病学传染病流行病学
临床研究的安全性

背景情况:

在临床研究期间对严重急性呼吸系统综合征冠状病毒2型 (SARS-CoV-2) 传播的担忧在整个大流行期间普遍存在.
高海拔的实地研究为实施和监测传染病控制措施带来了独特的挑战.

研究的目的:

在2021年在吉尔吉斯斯坦进行的高海拔实地研究中调查SARS-CoV-2感染的发生情况.
评估实施的COVID-19安全措施在研究环境中预防病毒传播的有效性.

主要方法:

研究涉及患有慢性阻塞性肺病 (COPD) 的患者和健康儿童在3,100米和3,250米的高度,以及760米的对照地点.
对参与者和工作人员进行了系统的SARS-CoV-2快速抗原测试 (RAT).
测量结果包括最初呈现的流行率和在参与研究期间和研究后不久的RAT阳性转化发生率.

主要成果:

在338名参与者和工作人员中,SARS-CoV-2感染的流行率为4.4%.
在参与研究和10天随访期间,只有0.4%的参与者检测出SARS-CoV-2阳性.
工作人员的转化率较高 (10.9%),但所有研究人员中SARS-CoV-2的整体平均每周发病率 (每周0.00%) 显著低于吉尔吉斯斯坦人口的背景发病率 (每周0.06%).

结论:

特定的安全措施有效地减少了高海拔临床研究期间的SARS-CoV-2传播.
与普通人口相比,参与者和工作人员中SARS-CoV-2感染的发生率明显较低.
这些发现为在类似的高海拔环境中进行临床研究提供了保证,并采取适当的预防措施.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.临床试验临床试验临床试验临床试验临床试验高海拔的高海拔地区.山的山的山,山的山,山的山.病毒传输病毒传输病毒传播

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