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Updated: Jun 28, 2025

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用人类DNA聚合酶β进行Fapy•dG复制的生物化学和结构特征

Shijun Gao1, Peyton N Oden2, Benjamin J Ryan2

  • 1Department of Chemistry, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.

Nucleic acids research
|April 18, 2024
PubMed
概括

突变性DNA损伤Fapy•dG导致G→T和G→A突变. DNA聚合酶β (Pol β) 绕过Fapy•dG,导致突变,而不是结合Fapy•dGTP,澄清Fapy•dGG.

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