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Updated: Jun 28, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Published on: May 9, 2025

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合成士兵:将T细胞转化为不朽的战士

Nicholas P Restifo1,2, Luca Gattinoni3,4,5

  • 1Marble Therapeutics , Boston, MA, USA.

The Journal of experimental medicine
|April 18, 2024
PubMed
概括

研究人员已经为先进的细胞疗法设计了合成T细胞状态. 破坏BCOR和ZC3H12A基因创造了强大的抗瘤T细胞,提高了寿命和疗效.

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