用venetoclax治疗的慢性淋巴细胞白血病患者的COVID-19严重程度:单中心观察队列研究
Sophie Thau1, Christian Bjørn Poulsen1, Christian Brieghel1
1Department of Hematology, Zealand University Hospital, Roskilde, Denmark.
Annals of hematology
|April 18, 2024
概括
在COVID-19期间对慢性淋巴细胞白血病 (CLL) 患者的Venetoclax治疗显示出低的住院和死亡率. 大多数患者经历了轻度的COVID-19,表明venetoclax是一种安全的选择.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 患有慢性淋巴细胞白血病 (CLL) 的患者面临严重COVID-19的高风险.
- 了解在接受特定治疗的CLL患者中COVID-19的结果至关重要.
研究的目的:
- 评估使用venetoclax治疗的CLL患者的COVID-19相关发病率和死亡率.
- 在COVID-19大流行期间评估Venetoclax在CLL患者中的安全性.
主要方法:
- 一项单中心研究包括108名CLL或小淋巴细胞淋巴瘤患者,他们接受了venetoclax治疗.
- 收集的数据包括PCR验证的SARS-COV-2感染,COVID-19严重程度,住院和30天死亡率.
- 统计分析确定了与严重的COVID-19相关的因素.
主要成果:
- 44%的患者感染了COVID-19;75%的患者无症状/轻度疾病.
- 30天死亡率为4%,严重的并发病是主要的死亡原因.
- 住院率为46%;在Omicron前和Omicron时代,结果相似.
结论:
- 接受Venetoclax治疗的CLL患者主要经历了轻度的COVID-19.
- 与一般的CLL人群相比,住院和死亡率较低.
- 威尼托克拉克斯似乎是大流行期间CLL患者的安全治疗方法.
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