疫苗开发用于严重发烧与血小板缩小综合征病毒在狗
Seok-Chan Park1, Da-Eun Jeong2, Sun-Woo Han3
1Bio-Safety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan, 54531, Republic of Korea.
Journal of microbiology (Seoul, Korea)
|April 18, 2024
概括
无活化SFTS病毒疫苗有效预防狗的严重发烧与血栓塞缩综合征 (SFTS) 和病毒病. 这项研究突出了SFTSV疫苗接种对控制这种病毒性动物感染在犬种群中的潜力.
科学领域:
- 兽医病毒学 兽医病毒学
- 免疫学 免疫学 免疫学
- 动物传播疾病 动物传播疾病
背景情况:
- 严重发烧与血小板缺血综合征 (SFTS) 是由SFTS病毒 (SFTSV) 引起的危及生命的病毒性 zoonosis.
- 家庭动物 (如狗) 在SFTSV向人类传播中的潜在作用需要制定预防策略.
- 迫切需要在犬群中采取有效的SFTSV控制措施,因为潜在的动物传播.
研究的目的:
- 评估甲失活的SFTSV疫苗在预防狗的SFTSV感染方面的有效性.
- 评估两种不同的辅助剂与非活化SFTSV疫苗结合时的安全性和免疫性.
- 确定疫苗对狗中SFTSV诱导的病毒病和病理的保护作用.
主要方法:
- 狗被免疫三次与甲无活化SFTSV和两种类型的辅助剂.
- 在最后一次免疫接种两周后,接种疫苗和对照犬被挑战SFTSV (KCD46).
- 感染后评估了临床症状,病毒病,脏病理 (白肉缩) 和亡 (TUNEL测定).
主要成果:
- 对照犬表现出病毒血症,脏白肉质缩以及增加TUNEL阳性区域.
- 接种疫苗的狗在脏中显著减少了病理变化和TUNEL阳性区域.
- 在接种疫苗的狗中没有检测到SFTSV,两种辅助剂都被发现是安全的,并诱导了强大的中和抗体.
结论:
- 甲失活的SFTSV疫苗,结合经过测试的辅助剂,在预防狗的致病性和病毒性方面是安全有效的.
- 这项研究证明了非活化SFTSV疫苗接种作为控制犬类SFTSV的可行策略的潜力.
- 这种方法可以有助于更广泛地控制SFTSV,减轻动物传播的传播风险.
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