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植物性饮食中的宏观营养成分和乳腺癌风险:E3N前性队列研究
Nicholas A Koemel1,2, Sanam Shah3, Alistair M Senior1,4
1Charles Perkins Centre, The University of Sydney, Sydney, Australia.
European journal of nutrition
|April 18, 2024
概括
植物性饮食质量显著影响乳腺癌风险. 高质量的植物性饮食,特别是低蛋白质摄入量,与乳腺癌风险最低相关.
科学领域:
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
- 饮食科学 饮食科学
背景情况:
- 植物性饮食越来越多地被认为是潜在的乳腺癌风险降低.
- 植物性饮食中宏观营养素组成对乳腺癌风险的具体影响仍然未得到充分研究.
研究的目的:
- 调查宏观营养素组成与乳腺癌风险之间的关联.
- 通过使用多维方法分析各种植物性饮食质量指数之间的这种关系.
主要方法:
- 一项从1993年至2014年对64,655名女性进行的前性队列研究 (Etude Epidémiologique auprès de femmes de la Mutuelle Générale de l'Education Nationale队列).
- 通过验证的问卷来评估饮食摄入量,以计算遵守植物性饮食指数 (PDI,hPDI,UPDI).
- 用于分析宏观营养素组成和乳腺癌风险关联的一般化添加剂依赖时间的考克斯模型.
主要成果:
- 总共有3932例乳腺癌病例被确定.
- 在所有植物性饮食指数 (P < 0.001) 中,在宏观营养素组成和乳腺癌风险之间发现了显著的关联.
- 较高的健康植物性饮食 (hPDI) 评分和最低的蛋白质摄入量 (10%) 观察到的乳腺癌风险最低;与高脂肪 (55%) 和低蛋白质/碳水化合物较低的hPDI相关的风险最高.
结论:
- 宏观营养素配置,植物性饮食质量和乳腺癌风险之间存在复杂的相互作用.
- 需要进一步的研究来确定驱动这些观察到的关联的特定食品成分.
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