有效的磁性固相提取,UPLC-MS/MS检测,以及对五种微量精神活性物质的消耗评估
Rong Zhu1, Shurui Cao2,3, Hongtao Su4
1College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
Environmental science and pollution research international
|April 18, 2024
概括
基于废水的流行病学有效监测精神活性物质的使用. 一种新的磁性生物炭吸附剂 (DZMBC) 能够准确地检测废水中的甲基胺等药物,揭示消费模式.
科学领域:
- 环境科学 环境科学
- 分析化学 分析化学
- 法医毒理学 法医毒理学
背景情况:
- 基于废水的流行病学 (WBE) 提供了客观的人口层面监测精神活性物质 (PS) 消费.
- 开发高效的提取方法对于准确的WBE分析至关重要.
研究的目的:
- 开发和验证一种用于从废水中提取PS的新型磁吸附剂.
- 使用UPLC-MS/MS.量化城市废水中的五个PS.
- 为了评估重庆的毒品消费模式.
主要方法:
- 优化PS吸附的磁性贝生物炭 (DZMBC) 的合成.
- 使用DZMBC进行PS预缩的磁性固体相提取 (MSPE).
- 超高性能液体染色学-并联质谱学 (UPLC-MS/MS) 用于定量分析.
主要成果:
- DZMBC表现出卓越的pH稳定性,抗干扰,磁性分离,可重复使用性和可重复性.
- 该MSPE-UPLC-MS/MS方法实现了低检测极限 (1.004.75 ng/L) 和高精度 (<4.8% RSD).
- 甲基胺 (MAMP) 和MDMA普遍存在;MDMA消费显示出显著的季节性变化.
结论:
- 基于DZMBC的MSPE方法对PSs的WBE有效.
- 这种方法提供了可靠的药物使用模式的快照.
- 在重庆发现了MDMA消费的显著季节性趋势.
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